Table I.
Clinical characteristics of normal-weight controls, women with PCOS and an index woman with PCOS and severely reduced serum AMH levels.
| Controls median* (quartiles) | PCOS median* (quartiles) | P-value | Index PCOS woman (Rank/14)** | |
|---|---|---|---|---|
| PCOS cohort vs controls | ||||
| Patient characteristics | n = 21 | n = 13 | n = 1 | |
| AMH (ng/ml) | 4.03 (2.47–6.11) | 10.82 (6.74–13.40) | <0.001 | 0.10 (1) |
| E2/Total T | 2 (1.05–3.83) | 1.04 (0.92–1.16) | 0.006 | 0.85 (4) |
| FSH (mIU/ml) | 5.3 (4.6–7) | 5.70 (4.80–5.90) | 0.834 | 5.60 (5) |
| AFC | 16 (14.5–21.5) | 46 (39–59) | <0.001 | 43 (6) |
| DHEAS (µg/dl) | 165 (116–202) | 217 (197–272) | 0.018 | 239 (9) |
| E1/A4 | 0.46 (0.37–0.77) | 0.35 (0.30–0.41) | 0.055 | 0.38 (9) |
| SHBG (nmol/L) | 71 (47–81) | 47 (34–61) | 0.12 | 60 (10) |
| E2 (pg/ml) | 60 (34–97) | 56 (41–67) | 0.675 | 76 (11) |
| Free T (pg/ml) | 2.2 (1.8–2.45) | 5.65 (4.75–6.60) | <0.001 | 7 (11) |
| Total T (ng/dl) | 30 (24.5–34.5) | 55.5 (49.5–62.5) | <0.001 | 89 (12) |
| LH (mIU/ml) | 7.8 (5.7–10.5) | 13.3 (6.8–14.7) | 0.055 | 23.9 (13) |
| A4 (ng/dl) | 111 (90–142) | 191 (134–230) | 0.004 | 380 (14) |
| E1 (pg/ml) | 58 (44–80) | 59 (53–73) | 0.506 | 145 (14) |
*
Median compared between groups using the Wilcoxon test.
**
Patient characteristics are sorted by rank of the PCOS index woman within the PCOS cohort.
A4, androstenedione; AFC, antral follicle count; AMH, anti-Müllerian hormone; DHEAS, dehydroepiandrosterone sulfate; E1, estrone; E2, estradiol; SHBG, sex hormone-binding globulin; T, testosterone.
Conversion to SI units: T (×0.0347 nmol/l), free T (×3.47 pmol/l), A4 (×0.0349 nmol/l), DHEAS (×0.0271 µmol/l), E1 (×3.699 pmol/l), E2 (×3.67 pmol/l), LH (×1.0 IU/l), FSH (×1.0 IU/l).