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. 2020 Sep 21;12:8703–8720. doi: 10.2147/CMAR.S268943

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© 2020 Han et al.

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Multidimensional Framework of CRC Evolution. The development of colorectal cancer (CRC) involves a complex interplay between various layers of extrinsic and intrinsic factors. (1) Inflammation represents an important intrinsic factor that promotes carcinogenesis by inducing DNA damage, and reactive oxygen and nitrogen species. (2) Metabolites of intestinal flora can influence intestinal tumorigenesis. (3) Specific bacterial species can influence CRC evolution. (4) Diet can modulate the composition and metabolic activity of the gut microbiota and influence CRC.