Table 3.
Vaccine program after CAR T-cell therapy in pediatric or adult patients with a previous HSCT
| Antigens (vaccines) | Time after HSCT | Recommended interval between doses | Number of doses |
|---|---|---|---|
| Diphteria, tetanus and pertussis (DTPa-dTpa/tD) |
6 months (dose 1) 7 months (dose 2) 8 months (dose 3) 18 months (dose 4) |
1–2 months | 4 |
| Poliomielitis (PI) |
6 months (dose 1) 7 months (dose 2) 8 months (dose 3) 18 months (dose 4) |
1 month | 4 |
| Haemophilus influenza b (Hib) |
6 months (dose 1) 7 months (dose 2) 8 months (dose 3) 18 months (dose 4) |
1 month | 4 |
| Hepatitis B (HB) |
6 months (dose 1) 7 months (dose 2) 8 months (dose 3) 18 months (dose 4) |
1–2 months | 4 |
| Meningococcus (MACWY) (MB) |
12 months (dose 1) 18 months (dose 2) |
12 months (12 and 18 months) | 2 |
| Pneumococcus (PN13) | Sequential schedule: | ||
| PN13: | 1–2 months | 3 | |
|
3 months (dose 1) 4 months (dose 2) 5 months (dose 3) |
1 | ||
| (PN23) | PN23: | 2 months after PN13 | 2 |
|
12–24 months (dose 1) 5 years after first dose of PN23 (dose 2) |
|||
| Hepatitis A (HA) |
6 months (dose 1) 12 months (dose 2) |
6 months | 2 |
| Influenza | 4–6 months (influenza season) | 1 month in first time vaccination of patients younger than 9 years | 1 (2 in first-time vaccination of patients younger than 9 years) |
| Papilloma virus (HPV) |
12 months (dose 1) 13–14 months (dose 2) 18 months (dose 3) |
1–2 months (between dose 1 and 2) 4 months (between dose 2 and 3) |
3 |
| Measles, mumps and rubella (MMR) |
24 months (only if no immunosupression or graft versus host disease are present and cell immunity is reconstituted) 24 months (dose 1) 25 months (dose 2) |
1 month | 2 |
| Varicella (VZ) |
24 months (only if no immunosupression or graft versus host disease are present and cell immunity is reconstituted) 24 months (dose 1) 25 months (dose 2) |
1 month | 2 |
HA hepatitis A vaccine, HSCT hematopoietic stem cell transplantation, MACWY meningococcal A, C, W and Y vaccine, MB meningococcal B vaccine, MMR measles, mumps and rubella vaccine, HPV human papillomavirus vaccine, PN13 pneumococcal conjugated vaccine, PN23 pneumococcal polysaccharide vaccine, VZ varicella vaccine