Table 2.
Cardiac function and morphometry in N1-Tg and N3-Tg mice 14 days after I/R
| Sham | I/R | |||||
|---|---|---|---|---|---|---|
| WT N = 19 |
N1-Tg N = 16 |
N3-Tg N = 8 |
WT N = 8 |
N1-Tg N = 17 |
N3-Tg N = 9 |
|
| FAC (%) | 61 ± 4 | 58 ± 6 | 54 ± 3 | 51 ± 7§§ | 54 ± 5 | |
| LVEDA (mm2) | 18.4 ± 3.0 | 19.2 ± 2.2 | 18.0 ± 1.5 | 18.9 ± 0.9 | 18.4 ± 2.7 | 20.0 ± 1.1 |
| LVESA (mm2) | 7.5 ± 1.3 | 7.5 ± 1.3 | 7.6 ± 1.1 | 8.6 ± 0.7 | 9.0 ± 0.7§ | 9.3 ± 1.3 |
| HR (bpm) | 567 ± 23 | 565 ± 31 | 559 ± 18 | 522 ± 25** | 551 ± 31# | 527 ± 23++ |
| BW (g) | 28 ± 3 | 29 ± 3 | 26 ± 3 | 28 ± 2 | 28 ± 3 | 28 ± 2 |
| HW (mg) | 107 ± 11 | 114 ± 13 | 108 ± 13 | 105 ± 9 | 129 ± 14§§## | 109 ± 9 |
| HW/BW | 3.9 ± 0.4 | 4.1 ± 0.7 | 4.2 ± 0.3 | 3.7 ± 0.2 | 4.8 ± 0.8§§## | 3.9 ± 0.2 |
All values are depicted as mean ± SD. Statistical analysis was done using Two-Way-ANOVA with Bonferroni post-test
FAC Fractional area change, LVEDA left ventricular end-diastolic area, LVESA left ventricular end-systolic area, HR heart rate, bpm beats per minute, BW body weight, HW heart weight
**P < 0.01 WT I/R vs. WT sham
§P < 0.05 N1-Tg I/R vs. N1-Tg sham
§§P < 0.01 N1-Tg I/R vs. N1-Tg sham
++P < 0.01 N3-Tg I/R vs. N3-Tg sham
#P < 0.05 N1-Tg I/R vs. WT I/R
##P < 0.01 N1-Tg I/R vs. WT I/R