Fig. 1.

Key advances in the recent history of breast cancer care (the date of introduction of each innovation was based on literature review with reference to first large studies confirming its clinical value). Specific evolutions or improvements are colour-coded. Imaging is in light blue, pathology in violet, surgery in red, radiation therapy in blue-green, systemic treatments in yellow. RT, radiation therapy: IHC, immunohistochemistry; MRI, magnetic resonance imaging; CDK4/6, cyclin-dependent kinase 4/6