FIGURE 2.

The defective NK cell maturation in Stat1^β/β mice reflects impaired IFNγ, but not IFNα/β, signaling. (A–E) Splenic NK cells (CD3ε^–NK1.1⁺) from WT, Stat1^β/β, Ifnar1^–/–, and Ifnar1^–/–Stat1^β/β (A,B), WT and Il27ra^–/– (C), WT, Stat1^β/β, Ifngr1^–/–, and Ifngr1^–/–Stat1^β/β (D,E) mice were analyzed for the maturation subsets CD27^–CD11b^–, CD27⁺CD11b^–, CD27⁺CD11b⁺, and CD27^–CD11b⁺ (A,C,D) and CD11b⁺KLRG1⁺ (B,E) by flow cytometry. Mean percentages ± SEM from eight (n = 5–18) (A,B), two (n = 12) (C) and six experiments (n = 10–14) (D,E) are depicted. *p < 0.05; **p < 0.01; ***p < 0.001.