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. 2020 Sep 25;10:15784. doi: 10.1038/s41598-020-72975-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Body weight (a), daily food intake (b), blood glucose levels (c), plasma FGF21 levels (d) and expression of hepatic FGF21 (e), ATF4 (f), Htr2a (g), and Sdf2l1 (h) in Tph1 mutant mice (Tph1KO) and wild-type mice (WT) fed a chow fat diet. The relative amount of mRNA is shown as fold-change of the mean value of the WT group in mice fed a chow diet. Data are presented as the mean ± SEM (n = 6/group). * P < 0.05.