Table 2.
Pathway analysis.
| Proteins involved | P-value | Gene symbol | |
|---|---|---|---|
| ECM assembly pathways | |||
| Assembly of collagen fibrils and other multimeric structures | 11 | 3.72e−17 | COL11A1, COL11A2, COL12A1, COL14A1, COL15A1, COL1A1, COL1A2, COL6A1, COL6A3, COL9A1, PCOLCE |
| Collagen biosynthesis and modifying enzymes | 11 | 7.47e−17 | COL11A1, COL11A2, COL12A1, COL14A1, COL15A1, COL1A1, COL1A2, COL6A1, COL6A3, COL9A1, PCOLCE |
| Crosslinking of collagen fibrils | 3 | 5.19e−05 | COL1A1, COL1A2, PCOLCE |
| Glycosaminoglycan metabolism | 4 | 0.00043 | BGN, CSPG4, FMOD, HSPG2 |
| Anchoring fibril formation | 2 | 0.0015 | COL1A1, COL1A2 |
| Chondroitin sulfate biosynthesis | 2 | 0.0021 | BGN, CSPG4 |
| Growth pathways | |||
| PI3K-Akt signalling pathway | 9 | 1.89e−08 | COL1A1, COL1A2, COL6A1, COL6A3, COL9A1, THBS1, THBS3, THBS4, TNC |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 2 | 0.0046 | MATN3, TNC |
| Biological processes | |||
| Tissue development | 10 | 0.0043 | COL11A1, COL11A2, COL12A1, COL1A1, COL6A1, CTHRC1, POSTN, TGFBI, THBS3, TNC |
| Cellular response to growth factor stimulus | 5 | 0.0128 | COL1A1, COL1A2, FMOD, POSTN, THBS1 |
| Regeneration | 3 | 0.0197 | MATN2, POSTN, TNC |
Table displays the results of the STRING and DAVID pathway analysis. The first (left) column shows the identified pathways and biological processes that are involved in ECM assembly, the second column shows the number of proteins of interest involved in that pathway/process, the third list the p-value of the upregulation and the fourth displays the gene symbols of the proteins involved. In total, 24 proteins were identified in 8 pathways and 3 biological processes.