Table 1.

Clinicopathological features of intrahepatic cholangiocarcinoma with IDH1/2 mutations.

	n	IDH1/2		P-value
		No mutation	mutation
Sex
M	121	110 (90.9%)	11 (9.1%)	0.999**
F	51	46 (90.2%)	5 (9.8%)
Age
<64 years	87	78 (89.7%)	9 (10.3%)	0.794
$\ge$64 years	85	78 (91.8%)	7 (8.2%)
Gross type
Mass forming	141	126 (89.4%)	15 (10.6%)	0.589^
Periductal infiltrative	8	8 (100%)	0
Intraductal growing	18	17 (94.4%)	1 (5.6%)
Mixed	5	5 (100%)	0
Differentiation
Well, moderate	117	110 (94.0%)	7 (6.0%)	0.031#
Poor	55	46 (83.6%)	9 (16.4%)
Histologic subtype
Bile ductular type	22	18 (81.8%)	4 (18.2%)	0.012^
Small duct type	68	58 (85.3%)	10 (14.7%)
Large duct type	82	80 (97.6%)	2 (2.4%)
Intraglandular and/or extraglandular mucin production
Absent	78	68 (87.2%)	10 (12.8%)	0.190
Present	94	88 (93.6%)	6 (6.4%)
Lymphatic emboli
Absent	102	91 (89.2%)	11 (10.8%)	0.594
Present	70	65 (92.9%)	5 (7.1%)
Venous invasion
Absent	95	87 (91.6%)	8 (8.4%)	0.793
Present	77	69 (89.6%)	8 (10.4%)
Perineural invasion
Absent	118	104 (88.1%)	14 (11.9%)	0.098**
Present	54	52 (96.3%)	2 (3.7%)
Chronic liver disease
Absent	130	118 (90.8%)	12 (9.2%)	1.000**
Present	42	38 (90.5%)	4 (9.5%)
BilIN*
Absent	102	88 (86.3%)	14 (13.7%)	0.010**
Present	65	64 (98.5%)	1 (1.5%)
T category
T1	48	44 (91.7%)	4 (8.3%)	0.887#
T2	52	47 (90.4%)	5 (9.6%)
T3	47	42 (89.4%)	5 (10.6%)
T4	25	23 (92.0%)	2 (8.0%)
N category
pN0	133	119 (89.5%)	14 (10.5%)	0.312#
pN1	39	37 (94.9%)	2 (5.1%)
M category
pM0	161	145 (90.1%)	16 (8.9%)	0.278#
pM1	11	11 (100%)	0
TNM staging
Stage I	40	36 (90.0%)	4 (10.0%)	0.280#
Stage II	37	33 (89.2%)	4 (10.8%)
Stage III	30	25 (83.3%)	5 (16.7%)
Stage IVA	54	51 (94.4%)	3 (5.6%)
Stage IVB	11	11 (100%)	0

*Biliary intraepithelial neoplasia; 5 cases could not be assessed for biliary intraepithelial neoplasia.

**Fisher’s exact test,

^Kruskal–Wallis test,

^#Wilcoxon’s rank-sum test.