Table 6.
Differentially methylated regions (DMRs) and associated CpGs found using Comb-p analysis.
| Genomic location | Number of CpGs | Nearby Gene | CpG site | Estimated average participant causal effect (APCE) | Fisher exact p-valuea |
|---|---|---|---|---|---|
| Chromosome 3 (146262175–146,262,422) | 2 |
PLSCR1 (software p-value = 0.0026) |
cg10679755 | 0.0252 − 0.0212 = 0.0040 | 0.0187 |
| cg23486067 | 0.0258 − 0.0194 = 0.0064 | 0.0154 | |||
| Chromosome 12 (123215011–123215554) | 9 |
GPR81 alias HCAR1 (software p-value = 0.0019) |
cg22534509 | 0.3834 − 0.3560 = 0.0274 | 0.0135 |
| cg05290737 | 0.3522 − 0.3328 = 0.0194 | 0.0153 | |||
| cg22972858 | 0.4241 − 0.4025 = 0.0216 | 0.0068 | |||
| cg20566840 | 0.4294 − 0.3998 = 0.0296 | 0.0428 | |||
| cg01306688 | 0.2559 − 0.2356 = 0.0203 | 0.1680 | |||
| cg19975916 | 0.2122 − 0.1987 = 0.0135 | 0.2715 | |||
| cg19328828 | 0.1503 − 0.1251 = 0.0252 | 0.1268 | |||
| cg23505823 | 0.3863 − 0.3537 = 0.0327 | 0.0499 | |||
| cg13702536 | 0.4898 − 0.4543 = 0.0355 | 0.0138 | |||
| Chromosome 6 (33560954–33561450) | 8 |
C6orf227 Alias LINC00336 (software p-value = 0.0084) |
cg04329454 | 0.2349 − 0.2018 = 0.0331 | 0.0039 |
| cg01392313 | 0.1600 − 0.1315 = 0.0284 | 0.0015 | |||
| cg06289138 | 0.1711 − 0.1535 = 0.0176 | 0.0949 | |||
| cg08301503 | 0.1479 − 0.1276 = 0.0203 | 0.0015 | |||
| cg07873320 | 0.1926 − 0.1852 = 0.0073 | 0.1752 | |||
| cg05602975 | 0.1069 − 0.0978 = 0.0091 | 0.0877 | |||
| cg19869469 | 0.1632 − 0.1454 = 0.0178 | 0.0007 | |||
| cg00536532 | 0.6582 − 0.6683 = − 0.0101 | 0.2623 |
aBased on 217 replications.