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. 2020 Sep 25;11:4855. doi: 10.1038/s41467-020-18634-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Representative membrane currents recorded in cell pairs of secondary astrocyte cultures (whole-cell configuration of the patch-clamp technique, holding potential −50 mV). Each chart recording illustrates the current recorded in the stimulated celI (I1, upper trace, in response to depolarizing voltage steps, 40 mV amplitude, 300 ms duration, every 30 s) and the junctional current recorded in the non-stimulated cell (I2, bottom trace). I1 and I2 were continuously monitored before and after the treatment of cells with either vehicle, CXCL12 (10 nM), CXCL11 (100 nM), or CBX (100 μM). b Time-course of the effect of CXCL12, CXCL11, and CBX on Ij magnitude. Perfusion of the recorded cell pairs with the different compounds started at the time indicated by the dotted line. Data are expressed as a percentage of Ij (normalized to the average ratio recorded during the first 4 min before any treatment). Values are means ± SEM (Two-way ANOVA, Bonferroni post-hoc, F(87,573)). c Ij before and after treatment for each cell pair recorded in the different conditions are plotted. Data are expressed as a percentage of Ij (normalized to the average ratio recorded during the first 4 min before any treatment, Two-tailed Wilcoxon test). See the Statistics and Reproducibility section for the number of repetitions, exact P values and symbol (*) legend. Source data are provided as a Source Data file.