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. 2020 Sep 24;11(9):798. doi: 10.1038/s41419-020-02921-z

Fig. 5. PIK3R3 knockdown suppresses cell proliferation and promotes cell senescence in vivo.

Fig. 5

a Tumor volume of three groups were measured over time. b Tumor gross observation of three groups (shNC, shPIK3R3, and shPIK3R3 + shp53). c Tumor weight of three groups (vector, PIK3R3, and PIK3R3 + p53). d IHC assays of PIK3R3, p53, p21, Ki-67, and β-Gal from three groups. e Quantification of p21 expression from three groups. f Quantification of the proportion of β-Gal-positive cells from three groups. g WB of PIK3R3, p53 and p21 in three different groups. These numeral results were displayed as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, t-test.