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. 2020 Sep 25;11:4873. doi: 10.1038/s41467-020-18526-1

Fig. 1. SNF to identify ASD molecular subtypes.

Fig. 1

a Overview of data integration and molecular subtyping to characterize the cascade of molecular changes in ASD. b Relationship between sample loadings on the first principal component of differential mRNA expression, miRNA expression, DNA methylation, and histone acetylation. c Identification of two sample clusters using SNF: SNF Group 1 and SNF Group 2. ASD samples in SNF Group 1 constitute the Disparate Subtype, whereas ASD samples in SNF Group 2 constitute the Convergent Subtype. d Number of samples classified into the two cluster groups using SNF and logistic regression (LR) classifiers. e Comparison of SNF clustering and logistic regression (LR) classification assignments when utilizing three out of four datasets (see Supplementary Fig. 5). The concordance of sample assignments to those when using the complete dataset are plotted.