Table 7.

Synthetic drugs and natural compounds regulate Alzheimer's disease by involving in SIRT1 in animal models.

Chemical agents	Models	Involved pathway	Effect	Reference
Resveratrol	OVX- and D-gal- induced AD rat model	SIRT1/NF-κB p65	Suppression of Aβ and MMP-9	Zhao et al. [105]
Resveratrol	AD mouse model induced by Aβ1–42	SIRT1/AMPK/PGC-1α/NLRP3/NF-κB	Improvement of cognitive deficits	Qi et al. [157]
Resveratrol	Tg2576 mouse AD model	SIRT1	Improvement of learning and memory, suppression of neural apoptosis	Wang et al. [163]
Resveratrol	Diabetes and AD rat model	SIRT1	Improvement of memory deficits	Ma et al. [164]
Resveratrol	APP/PS1 AD mice	SIRT1	Decrease of senile plaques and antioxidant effects	Dong et al. [165]
Resveratrol	APP/PS1 AD mice	SIRT1/ERK1/2	Improvement of learning and memory and decrease of Aβ	Cao et al. [166]
Resveratrol	APP/PS1 AD mouse model	SIRT1/AMPK	Improvement of memory loss and decrease of amyloid burden	Porquet et al. [167]
Resveratrol	AD rat model induced by Aβ1–42	SIRT1/CREB	Improvement of spatial, learning, and memory	Wang et al. [168]
—	3xTg AD mouse model	SIRT1/BDNF	SIRT1-transgenic mice improve cognitive behavior and decrease Aβ and tau pathology	Corpas et al. [169]
SLAB51	3xTg AD mouse model	SIRT1	Antioxidant effects	Bonfili et al. [170]
24-OH	hTau mice	SIRT1	Decrease of hyperphosphorylated tau protein	Testa et al. [171]
Acetylshikonin	D-galactose-induced AD mouse model	SIRT1/p53/p21	Improvement of cognitive impairment and hippocampus senescence	Li et al. [172]
Melatonin	Aβ-induced AD mouse model	SIRT1/TFAM	Improvement of memory and hippocampal cell damage	Ansari Dezfouli et al. [173]
Dihydromyricetin	Aβ-induced AD rat model	AMPK/SIRT1	Improvement of cognitive function and suppression of inflammatory responses and cell apoptosis	Sun et al. [174]
Salidroside	D-gal-induced AD rat model	SIRT1/NF-κB	Suppression of inflammatory responses	Gao et al. [175]

D-gal: D-galactose; OVX: ovariectomized; Aβ: amyloid-β; APP: amyloid precursor protein; PS1: presenilin 1.