Table 2.
Patient selection for IORT: disease, treatment sequence and radiation dose recommendations.
| Disease status | |
|---|---|
| Clinical setting | primary locally advanced rectal cancer |
| Indications | Potentially Resectable |
| Stage | T3-T4 |
| Treatment | |
| Preoperative chemo/RT followed by resection + IOERT boost | |
| Radiotherapy dose | |
| IORT boost | 10 to 12.5 Gy for negative resection margins (R0) 12.5 to 15 Gy for microscopic positive resection margins (R1) 15 to 20 Gy for macroscopic or gross residual tumor (R2) |
| External Beam Radiation Therapy (EBRT) | 45–50 Gy (in 25–28 fractions) |