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. 2020 Sep 24;6(3):740–748. doi: 10.1016/j.bioactmat.2020.08.036

Fig. 4.

Fig. 4

(a) Blood concentration of Zn2+ at different time points after i. v. injection of ZIF-8 and ZIF-8-0.6 GPa (25 mg/kg). Inset is half-life of Zn2+ for ZIF-8 and ZIF-8-0.6 GPa Mean ± SD (n = 3). *, P < 0.05. The pharmacokinetics of Zn2+ follows the two-compartment model; (b) Biodistribution of ECA-109 tumor bearing mice after i. v. injection of ZIF-8 (25 mg/kg) and ZIF-8-0.6 GPa (25 and 50 mg/kg) for 24 h. Mean ± SD (n = 3); (c, d) Serum biochemistry data and (e) TNF-α of healthy mice after i. v. injection of ZIF-8 (25 mg/kg) and ZIF-8-0.6 GPa (25 and 50 mg/kg) for 7 days. Mean ± SD (n = 3); (f) Biodistribution of health mice after i. v. injection of ZIF-8-0.6 GPa (50 mg/kg) at different times. Mean ± SD (n = 3).