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. 2019 Oct 21;117(38):23304–23310. doi: 10.1073/pnas.1913658116

Fig. 3.

Fig. 3.

Differential recruitment of Drd1 and Drd2 SPNs in ventrolateral vs. medial striatum. (A) Cartoon depiction of the location of ventrolateral (VLS) and medial (MS) striatal regions and representative high-magnification 40× images showing Egr2 expression within Drd1- or Drd2-expressing SPNs in VLS (Left) and MS (Right) in control vs. cocaine. (B and C) Scatter plots of Egr2 expression as a function of Drd1 or Drd2 expression within single cells in the VLS (B) and MS (C); n = 6 sections from 3 mice in each condition; VLS, 18,165 to 18,622 cells; MS, 31,008 to 31,920 cells. P < 0.0001. (D and E) Cocaine-induced Egr2 expression correlates with Drd1 expression in the VLS (D), and Drd1, as well as Drd2 expression in the MS (E). Each dot represents the mean gene expression for each replicate bin, while the line represents the mean. n = 6 sections from 3 mice for each condition; VLS, 18,165 to 18,622 cells; MS, 31,008 to 31,920 cells (P < 0.005 for all conditions except VLS Drd2, which was nonsignificant; ANOVA).