Table 1.

Studies describing secreted AGR2 in mammalian cell models.

Cancer	Mammalian cell models	AGR2 implications	References
Pancreatic	BxPC3, MiaPaCa-2, CFPAC-1, HPAC, Panc-1, Aspc-1, SU.86.86	eAGR2 levels correlate with increase rates of pancreatic cancer cell survival, proliferation, and invasion	[116]
	MiaPaca-2	eAGR2 promotes pancreatic cancer metastasis	[77]
Breast	MCF7A, RAMA 37	eAGR2 is O-glycosylated	[93]
	MCF-7, T47D	eAGR2 promotes the IGF-1-induced EMT of estrogen receptor-positive breast cancer cells	[31]
	MCF-7	eAGR2 is detected from cancer-cell spent media. Three times higher than prostate 22Rv1 cells	[117]
Lung Adenocarcinoma	H23, HBEC-AGR2	eAGR2 is secreted in the medium and interacts with ECM components	[74]
Gastric signet-ring carcinoma	Tu-katoIII, HSC-39	eAGR2 activates stromal fibroblasts and stimulates invasion by fibroblasts and cancer cells	[118]
Prostate	PCa, PC3, PC3M-Luc, HUVECs, RWPE-1	eAGR2 directly interacts with VEGFA and promotes metastasis	[61]
	LuCaP	eAGR2 induce the formation of cellular protrusions in prostate stromal cells	[37]
	PC3	eAGR2 promotes prostate cancer metastasis	[77]
	22Rv1	eAGR2 is detected from cancer-cell spent media	[117]
Colorectal	HT-29, SW48	eAGR2 promotes invasion of colorectal cancer cell	[76]
Ovarian	ES-2, A2780, SKOV3	eAGR2 promotes angiogenesis and invasion	[75]
Brain/Glioblastoma	U87, LN18	eAGR2 promotes chemotaxis and tube formation in HUVECs	[71]