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The effect of sex differences on the plasma TNF-α level in rats following administration of a high dose of LPS injection after LPS preconditioning is demonstrated. Data are presented as mean±SEM (n=8). *LPS-PC groups versus control groups (P<0.05 septic shock), #LPS-PC groups versus septic shock groups (P<0.05), $Female septic shock and LPS-PC groups versus male septic shock and LPS-PC groups (P<0.05), TNF-α: Tumor Necrosis Factor- α
