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Genes with differentially mutation frequency in PSs and MSs.
| Gene | Alteration frequency in primary ICC (%) | Alteration frequency in metastatic ICC (%) | P value | Pathway |
|---|---|---|---|---|
| LRP1B | 10.5 | 22.4 | 0.03 | None |
| BRAF | 11.1 | 0 | 0.01 | RTK.RAS |
| EPCAM | 0 | 4.0 | 0.01 | None |
| GNA13 | 0 | 4.0 | 0.01 | None |
| MYCL | 0 | 4.0 | 0.01 | None |
| PARP2 | 0 | 4.0 | 0.01 | DDR |
| YES1 | 0 | 4.0 | 0.01 | None |
| STK24 | 0.7 | 6.1 | 0.01 | None |
| TSC1 | 2.0 | 8.1 | 0.04 | PI3K |
