Table 2.
qRT-PCR data analysis of E6/E7-related miRNAs in different HPV subtypes.
| miR-9 | miR-21 | miR-27b | miR-34a | |
|---|---|---|---|---|
| Compared with Normal | 2–ΔΔCt (P value) | |||
| HPV16 CC (n = 44) | 0.809 (0.668) | 1.892 (0.106) | 2.360 (0.072) | 3.609 (0.005)∗∗ |
| HPV52 CC (n = 16) | 0.438 (0.233) | 1.025 (0.964) | 1.409 (0.586) | 1.708 (0.502) |
| HPV58 CC (n = 12) | 0.418 (0.096) | 1.523 (0.448) | 0.651 (0.515) | 0.996 (0.993) |
| HPV16 CIN (n = 15) | 1.096 (0.860) | 0.524 (0.194) | 3.166 (0.076) | 0.907 (0.893) |
| HPV52 CIN (n = 15) | 0.792 (0.630) | 0.850 (0.692) | 1.246 (0.721) | 0.315 (0.133) |
| HPV58 CIN (n = 11) | 0.200 (0.003)∗∗ | 0.822 (0.689) | 0.534 (0.563) | 0.801 (0.662) |
| Comparison between groups | ||||
| HPV16 CC vs. HPV52 CC | 1.848 (0.444) | 1.847 (0.305) | 1.675 (0.433) | 2.113 (0.323) |
| HPV16 CC vs. HPV58 CC | 1.937 (0.443) | 1.242 (0.735) | 3.623 (0.074) | 3.625 (0.099) |
| HPV52 CC vs. HPV58 CC | 1.048 (0.956) | 0.673 (0.656) | 2.163 (0.399) | 1.716 (0.596) |
| HPV16 CIN vs. HPV52 CIN | 1.384 (0.648) | 0.616 (0.413) | 2.541 (0.276) | 2.883 (0.283) |
| HPV16 CIN vs. HPV58 CIN | 5.476 (0.034)∗ | 0.637 (0.524) | 5.926 (0.125) | 1.132 (0.891) |
| HPV52 CIN vs. HPV58 CIN | 3.957 (0.054) | 1.034 (0.948) | 2.333 (0.441) | 0.393 (0.315) |
| HPV16 CC vs. HPV16 CIN | 0.739 (0.703) | 3.612 (0.028)∗ | 0.745 (0.661) | 3.979 (0.067) |
| HPV52 CC vs. HPV52 CIN | 0.553 (0.454) | 1.206 (0.785) | 1.130 (0.884) | 5.429 (0.108) |
| HPV58 CC vs. HPV58 CIN | 2.088 (0.309) | 1.854 (0.440) | 1.219 (0.866) | 1.243 (0.784) |
∗ P < 0.05; ∗∗P < 0.01.