Table 2.
Univariate analysis of prognostic factors in patients with rhabdomyosarcoma.
| Variables | Classification | Cancer-specific mortality (%) | P | Non-cancer-specific mortality (%) | P | ||||
|---|---|---|---|---|---|---|---|---|---|
| 1 year | 3 years | 5 years | 1 year | 3 years | 5 years | ||||
| Total | 15.7 | 35.3 | 39.5 | <0.001 | 4.7 | 7.4 | 8.7 | <0.001 | |
| Age | <19 | 8.3 | 26.3 | 31.3 | <0.001 | 0.5 | 1.4 | 2.0 | <0.001 |
| ≥19 | 26.1 | 47.9 | 51.1 | 10.7 | 16.0 | 18.2 | |||
| Year | 1986–1995 | 16.4 | 34.9 | 39.7 | 0.967 | 2.5 | 4.8 | 5.8 | 0.001 |
| 1996–2005 | 15.7 | 35.8 | 39.6 | 4.7 | 6.6 | 7.4 | |||
| 2006–2015 | 15.6 | 34.9 | 39.4 | 5.2 | 8.8 | 10.5 | |||
| Race | White | 15.1 | 33.8 | 37.9 | 0.022 | 5.0 | 8.0 | 9.2 | 0.022 |
| Black | 17.7 | 40.0 | 43.3 | 4.7 | 6.7 | 8.0 | |||
| Other | 17.3 | 38.3 | 45.5 | 2.8 | 4.8 | 5.7 | |||
| Sex | Male | 17.1 | 35.9 | 40.6 | 0.269 | 6.3 | 9.2 | 10.3 | 0.011 |
| Female | 14.6 | 34.7 | 38.6 | 3.5 | 6.1 | 7.4 | |||
| Marital | Married | 27.1 | 48.1 | 51.1 | <0.001 | 10.3 | 16.8 | 19.3 | <0.001 |
| Unmarried | 11.0 | 30.6 | 35.5 | 1.5 | 2.7 | 3.5 | |||
| DSW | 31.7 | 46.8 | 47.7 | 21.6 | 29.3 | 31.8 | |||
| Site | Favorable | 12.9 | 28.7 | 32.0 | <0.001 | 4.0 | 6.4 | 7.1 | <0.001 |
| Unfavorable | 17.1 | 38.5 | 43.2 | 5.1 | 7.9 | 9.5 | |||
| Historic stage | Localized | 5.8 | 16.1 | 19.1 | 0.000 | 2.8 | 5.8 | 7.9 | 0.841 |
| Regional | 11.8 | 30.1 | 34.7 | 4.7 | 7.0 | 8.1 | |||
| Distant | 30.0 | 60.0 | 65.2 | 6.7 | 9.6 | 10.1 | |||
| Tumor size | <5 | 6.6 | 19.7 | 22.4 | 0.000 | 2.1 | 4.9 | 6.5 | 0.013 |
| 5–10 | 11.6 | 33.2 | 38.0 | 4.1 | 6.2 | 7.5 | |||
| ≥10 | 26.2 | 47.4 | 51.9 | 7.4 | 10.3 | 11.6 | |||
| Other | 20.8 | 43.0 | 47.7 | 5.9 | 9.0 | 9.7 | |||
| Laterality | Not a paired site | 14.6 | 34.6 | 38.1 | <0.001 | 4.5 | 7.2 | 8.2 | <0.001 |
| Left | 12.9 | 29.1 | 34.3 | 3.4 | 5.5 | 7.2 | |||
| Right | 17.4 | 38.0 | 42.1 | 5.4 | 8.3 | 9.5 | |||
| HS | RMS | 26.7 | 44.8 | 48.4 | 0.000 | 10.3 | 15.5 | 18.2 | 0.000 |
| Embryonal | 9.4 | 23.1 | 26.7 | 1.5 | 2.3 | 2.5 | |||
| Alveolar | 14.7 | 47.0 | 53.3 | 2.3 | 4.6 | 5.9 | |||
| Pleomorphic | 26.2 | 43.4 | 45.4 | 14.0 | 20.4 | 23.1 | |||
| Other | 11.3 | 24.3 | 29.0 | 3.8 | 6.6 | 7.5 | |||
| RS | NRS | 20.2 | 39.7 | 43.3 | <0.001 | 5.9 | 8.9 | 10.0 | <0.001 |
| WRS | 7.5 | 26.9 | 32.3 | 2.6 | 4.8 | 6.3 | |||
| IRS | 5.6 | 27.8 | 33.3 | 0.0 | 0.0 | 0.0 | |||
| Surgery | Yes | 11.7 | 27.2 | 31.6 | 0.000 | 4.5 | 7.4 | 9.0 | 0.053 |
| No/unknown | 22.5 | 48.7 | 52.7 | 5.1 | 7.6 | 8.2 | |||
| Chemotherapy | Yes | 14.2 | 34.8 | 39.4 | 0.172 | 2.4 | 4.5 | 5.4 | 0.000 |
| No/unknown | 23.7 | 37.6 | 39.9 | 16.8 | 22.5 | 26.0 | |||
| Radiotherapy | Yes | 10.5 | 32.6 | 37.6 | <0.001 | 2.7 | 4.8 | 5.7 | <0.001 |
| None/unknown | 22.6 | 38.7 | 41.9 | 7.5 | 10.9 | 12.5 | |||
DSW: divorced and separated and widowed; RMS: rhabdomyosarcoma; HS: histology subtype; RS: radiation sequence with surgery; NRS: no radiation and/or cancer-directed surgery; WRS: radiation prior to surgery, radiation after surgery, and radiation before and after surgery; IRS: intraoperative radiation and intraoperative rad with other rad before/after surgery.