Table 3.
Proportional subdistribution hazards models for rhabdomyosarcoma.
| Variables | Classification | DTR | P | DOC | P | ||
|---|---|---|---|---|---|---|---|
| Coefficient | sdHR (95% CI) | Coefficient | sdHR (95% CI) | ||||
| Age | <19 | Reference | Reference | ||||
| ≥19 | 0.650 | 1.915 (1.586–2.314) | <0.001 | 1.091 | 2.978 (1.879–4.720) | <0.001 | |
| Year | 1986–1995 | Reference | Reference | ||||
| 1996–2005 | −0.260 | 0.771 (0.625–0.950) | 0.015 | −0.156 | 0.856 (0.570–1.284) | 0.452 | |
| 2006–2015 | −0.430 | 0.650 (0.527–0.803) | <0.001 | −0.170 | 0.844 (0.572–1.244) | 0.391 | |
| Race | Black | Reference | Reference | ||||
| White | −0.178 | 0.837 (0.705–0.993) | 0.042 | 0.069 | 1.071 (0.734–1.563) | 0.722 | |
| Other | −0.138 | 0.871 (0.663–1.145) | 0.322 | −0.704 | 0.495 (0.232–1.056) | 0.069 | |
| Sex | Female | Reference | Reference | ||||
| Male | −0.046 | 0.955 (0.832–1.097) | 0.517 | 0.184 | 1.202 (0.918–1.573) | 0.180 | |
| Marital status | DSW | Reference | Reference | ||||
| Married | 0.010 | 1.010 (0.747–1.367) | 0.947 | −0.565 | 0.569 (0.406–0.795) | 0.001 | |
| Unmarried | −0.142 | 0.868 (0.629–1.198) | 0.388 | −0.963 | 0.382 (0.249–0.585) | <0.001 | |
| Site | Favorable | Reference | Reference | ||||
| Unfavorable | 0.216 | 1.241 (1.050–1.467) | 0.011 | 0.313 | 1.367 (0.996–1.877) | 0.053 | |
| Historic stage | Distant | Reference | Reference | ||||
| Localized | −1.225 | 0.294 (0.239–0.362) | <0.001 | −0.215 | 0.806 (0.546–1.191) | 0.280 | |
| Regional | −0.695 | 0.499 (0.425–0.585) | <0.001 | −0.063 | 0.939 (0.657–1.343) | 0.732 | |
| Tumor size | 5–10 | Reference | Reference | ||||
| <5 | −0.170 | 0.843 (0.681–1.044) | 0.118 | −0.189 | 0.827 (0.561–1.221) | 0.340 | |
| ≥10 | 0.370 | 1.447 (1.199–1.747) | <0.001 | −0.228 | 0.796 (0.545–1.163) | 0.238 | |
| Other | 0.074 | 1.077 (0.894–1.298) | 0.435 | −0.112 | 0.894 (0.612–1.306) | 0.563 | |
| Laterality | Left | Reference | Reference | ||||
| Not a paired site | 0.067 | 1.070 (0.865–1.323) | 0.535 | 0.202 | 1.223 (0.811–1.846) | 0.337 | |
| Right | 0.120 | 1.128 (0.941–1.351) | 0.192 | 0.316 | 1.371 (0.948–1.982) | 0.094 | |
| HS | Alveolar | Reference | Reference | ||||
| RMS | −0.253 | 0.777 (0.625–0.965) | 0.022 | 0.384 | 1.468 (0.954–2.258) | 0.081 | |
| Embryonal | −0.483 | 0.617 (0.517–0.736) | <0.001 | −0.375 | 0.687 (0.418–1.130) | 0.139 | |
| Pleomorphic | −0.208 | 0.813 (0.606–1.090) | 0.166 | 0.266 | 1.305 (0.794–2.145) | 0.294 | |
| Other | −0.470 | 0.625 (0.459–0.852) | 0.003 | 0.067 | 1.069 (0.554–2.063) | 0.842 | |
| RS | IRS | Reference | Reference | ||||
| NRS | 0.447 | 1.564 (0.586–4.176) | 0.372 | −0.012 | 0.988 (0.157–6.205) | 0.989 | |
| WRS | 0.419 | 1.520 (0.584–3.954) | 0.391 | 0.803 | 1.255 (0.211–7.457) | 0.803 | |
| Surgery | No/unknown | Reference | Reference | ||||
| Yes | −0.328 | 0.720 (0.587–0.884) | 0.002 | −0.195 | 0.823 (0.545–1.244) | 0.356 | |
| Chemotherapy | No/unknown | Reference | Reference | ||||
| Yes | 0.200 | 1.222 (0.959–1.557) | 0.105 | −0.792 | 0.453 (0.328–0.626) | <0.001 | |
| Radiotherapy | None/unknown | Reference | Reference | ||||
| Yes | −0.148 | 0.862 (0.700–1.062) | 0.163 | −0.459 | 0.632 (0.389–1.026) | 0.064 | |
DSW: divorced and separated and widowed; RMS: rhabdomyosarcoma; HS: histology subtype; RS: radiation sequence with surgery; NRS: no radiation and/or cancer-directed surgery; WRS: radiation prior to surgery, radiation after surgery, and radiation before and after surgery; IRS: intraoperative radiation and intraoperative rad with other rad before/after surgery.