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. 2020 Sep 26;17:283. doi: 10.1186/s12974-020-01952-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Chronic low-grade systemic inflammation promotes neuronal loss and synaptic dysfunction in TDP-43 AAV9 mice. a Brain weights of mice during the sacrifice. b Representative images depicting the number of NeuN-positive neurons. Scale bar = 20 μm. c Quantification of neurons per field is analyzed in the frontal cortex of the mouse brain. Statistical analysis was carried out by one-way ANOVA with Bonferroni post hoc test (n = 4 mice/group; *p < 0.05). d Western blot analysis of synaptic markers in the frontal cortex of the mouse brain. e Quantification of synaptic markers. Statistical analysis was carried out by one-way ANOVA with Bonferroni post hoc test (n = 4 mice/group; *p < 0.05)