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. 2020 Sep 25;20:465. doi: 10.1186/s12935-020-01493-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Circ_002117 binds to miR-370. a circ_002117 binding sites on miR-370 predicted by CircInteractome. b Targeting relationship between miR-370 and circ_002117 determined by dual luciferase assay. c Interaction between circ_002117 and Ago2 determined by RIP. d Interaction between circ_002117 and miR-370 determined by RIP. e Subcellular co-localization of circ_002117 and miR-370 determined by FISH (×500). f miR-370 expression in AGS cells after overexpression of circ_002117 determined by RT-qPCR. *p < 0.05 vs. mimic NC or IgG. ^#p < 0.05 vs. NC-bio-probe or oe-NC. Data are shown as the mean ± standard deviation. Data between two groups were analyzed unpaired t-test. Data among multiple groups was analyzed by Tukey’s test-corrected ANOVA. The experiment was in triplicate