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. 2020 Sep 26;9:25. doi: 10.1186/s40164-020-00182-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Upregulated miR-100 or downregulated mTOR inhibited cell proliferation and arrested the cell cycle in MCL cells. a CCK-8 assay detected the OD value of cell proliferation in Jeko-1 cells. b Cell proliferation of Jeko-1 cells in the LV-miR-100-up group (day 3 p = 0.0026; day 4 p < 0.0001; day 5 p = 0.0002) and the LV-mTOR-RNAi group (day 2 p = 0.0062; day 3 p = 0.0002; day 4 p = 0.0003; day 5 p < 0.0001) was lower than that in the control and NC groups. c CCK-8 assay detected the OD value of the cell proliferation in Mino cells. d The data demonstrated that the cell proliferation of Mino cells in the LV-miR-100-up group (day 1 p = 0.0424; day 2 p = 0.0447; day 3 p = 0.0005; day 4 p = 0.0001; day 5 p < 0.0001) and the LV-mTOR-RNAi group (day 2 p = 0.0261; day 3 p < 0.0001; day 4 p < 0.0001; day 5 p < 0.0001) was lower than that in the control and NC groups. e Flow cytometry analyzed the cell cycle of Jeko-1 cells. f The data showed that the G1 cell cycle rates of Jeko-1 cells in the LV-miR-100-up and LV-mTOR-RNAi groups were higher than those in the NC group and control group, and the Jeko-1 S cell cycle rate in the LV-miR-100-up and LV-mTOR-RNAi groups was lower than those in the NC group and control group (p < 0.0001). g Flow cytometry analyzed the cell cycle of Mino cells. h The data showed that the G1 cell cycle rates of Mino cells in the LV-miR-100-up and LV-mTOR-RNAi groups were higher than those in the NC group and control group, and the S cell cycle rates in the LV-miR-100-up and LV-mTOR-RNAi groups were lower than those in the NC group and control group (p < 0.0001)