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. 2020 Sep 21;12:8685–8693. doi: 10.2147/CMAR.S254617

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© 2020 Han et al.

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CORO1C was a direct target for miR-133a-3p.

Notes: (A) Binding module between miR-133a-3p and CORO1C. (B) Increased expression of CORO1C in HCC tissues compared with normal tissues. (C) Increased expression of CORO1C in HCC cells compared with normal cell. (D) Luciferase activity in cells transfected with miR-133a-3p mimic/NC-mimic or CORO1C-wt/mt. (E) Decreased mRNA expression of CORO1C in HCC cells after miR-133a-3p mimic transfection. (F) Decreased protein expression of CORO1C in HCC cells after miR-133a-3p mimic transfection. ***P<0.001.

Abbreviations: miR-133a-3p, microRNA-133a-3p; HCC, hepatocellular carcinoma; NC-mimic, negative control miRNA for miR-133a-3p mimic; wt, wild-type; mt, mutant; CORO1C, coronin-like actin-binding protein 1C.