Table 2.
Major outcomes of study cohort
| Characteristics | n = 88 | Routine (43) | HAT (45) | p value |
|---|---|---|---|---|
| Mortality (%) | 49 (55) | 23 (53) | 26 (57) | 0.4 |
| Time to reversal of septic shock (hours) | 39.8 ± 23.9 | 45.42 ± 24.4 | 34.58 ± 22.63 | 0.03 |
| Mean vasoactive inotropic score on admission | 8.39 ± 10.47 | 7.89 ± 10.66 | 8.86 ± 10.38 | 0.66 |
| Highest vasoactive inotropic score | 45.9 ± 71.5 | 45.4 ± 64.1 | 46.3 ± 78.7 | 0.93 |
| Mean vasoactive inotropic score | 8.3 ± 12.4 | 8.86 ± 12.5 | 7.77 ± 12.12 | 0.6 |
| Mechanical ventilation | 44 (50%) | 20 (46.5) | 22 (48.8) | 0.4 |
| Ascorbic acid levels | ||||
| Before regimen | 1.8 ± 2.07 | 1.49 ± 1.39 | 2.1 ± 2.61 | 0.15 |
| After regimen | 51.8 ± 91.1 | 2.2 ± 4.1 | 94.2 ± 107.42 | <0.001 |
| SOFA@ 72 hours | 9.11 ± 3.7 | 9.3 ± 3.8 | 8.9 ± 3.6 | 0.7 |
| ∆SOFA | 1.83 ± 2.7 | 1.38 ± 3.1 | 2.23 ± 2.4 | 0.22 |
| New onset of AKI | 12 (14) | 5 (12) | 7 (15) | 0.4 |
| Procalcitonin on day 3 | 12.38 ± 21.4 | 18.97 ± 27.90 | 6.73 ± 11.5 | 0.03 |
| Procalcitonin clearance at 72 hours | 682.8 ± 2288.72 | 152.7 ± 478.2 | 1118.3 ± 3012.9 | 0.1 |
| Lactate on day 3 | 1.65 ± 0.91 | 1.79 ± 1.11 | 1.63 ± 0.85 | 0.9 |
| Lactate clearance at 24 hours | 5.98 ± 58.04 | 10.38 ± 44.14 | 2.1 ± 68.26 | 0.5 |
| ICU LOS | 10.49 ± 11.78 | 8.44 ± 8.16 | 12.44 ± 14.2 | 0.1 |
| Hospital LOS | 26.38 ± 25.0 | 20.9 ± 15.01 | 31.58 ± 31.06 | 0.043 |