Fig. 2.

miRNAs and their targets involved in the regulation of autophagy which affects drug sensitivity in breast cancer cells

miRNAs affect autophagy by precisely regulating the expression of autophagic related proteins, thereby affecting the drug resistance of breast cancer cells. PI3K: phosphoinositide 3-kinase; VPS34: the class III PI3K vacuolar protein sorting 34; ULK1: unc-51-like autophagy activating kinase 1; FIP200: FAK family kinase-interacting protein of 200 kDa; ATG: autophagy-related gene; mTORC1: mammalian target of rapamycin complex 1; AKT: protein kinase B; UCP2: uncoupling protein 2; PAD2: peptidylarginine deiminases 2; PTEN: phosphatase and tensin homologue; HMGB1: high mobility group box 1 protein; LAPTM4B: lysosomal protein transmembrane 4 β