Table 1.

miRNAs involved in the regulation of autophagy which affects drug sensitivity in breast cancer cells

miRNA	Target	Autophagy protein/pathway	Autophagy	Sensitivity	Cell type	Reference
miR-214	UCP2	AKT/mTOR	↓	↑ (Endo)	MCF7/LCC9 cells	Yu et al., 2015
miR-125b-5p	PAD2	AKT/mTOR	↑	↑ (Endo)	MCF7/TamR cellsa	Li et al., 2019
miR-21	PTEN	PI3K-AKT-mTOR	↓	↓ (Endo)	MCF-7 cells	Yu et al., 2016
miR-25	ULK1	ULK1	↓	↓ (Chemo)	MCF-7/ADR cellsb	Wang et al., 2014
miR-124-3p	Beclin 1	Beclin 1	↓	↑ (Endo)	MCF-7 cells	Zhang et al., 2016
miR-30a	Beclin 1	Beclin 1	↓	↑ (Chemo)	MCF-7 cells	Zou et al., 2012
miR-375	ATG7	ATG7	↓	↑ (lapatinib and imatinib)	FRBC cellsc	Liu et al., 2018
miR-129-5p	HMGB1	HMGB1	↓	↑ (Chemo)	MCF-7 cells	Shi et al., 2019
miR-489	LAPTM4B	LAPTM4B	Block maturation	↑ (Chemo)	Multiple breast cancer cells	Soni et al., 2018

UCP2: uncoupling protein 2; PAD2: peptidylarginine deiminases 2; PTEN: phosphatase and tensin homologue; ULK1: unc-51-like autophagy activating kinase 1; ATG7: autophagy-related gene protein 7; HMGB1: high mobility group box 1 protein; LAPTM4B: lysosomal protein transmembrane 4 β; AKT: protein kinase B; mTOR: mammalian target of rapamycin; PI3K: phosphoinositide 3-kinase; Endo: endocrine drug; Chemo: chemotherapeutic drug.

^aTamoxifen-resistant MCF7 cells;

^bAdriamycin-resistant MCF7 cells;

^cFulvestrant-resistant MCF7 cells