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. 2020 Sep 25;10:15780. doi: 10.1038/s41598-020-72804-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Determination of a low and high cut-off for detection of infection. (a) Quantification of urinary 2-MPC in A. lumbricoides-positive (red, n = 195) subjects, endemic controls (green, n = 858) and healthy Belgian controls (blue, n = 214). Grey area indicates samples that were below lower limit of quantification (1 ng/mL). A low cut-off to identify A. lumbricoides-infected subjects was determined using ROC analysis of A. lumbricoides-positive vs. healthy controls and found to be 21.7 ng/mL. (b) Correlation between urinary 2-MPC and A. lumbricoides DNA detection in stool collected in Kenya (expressed in A. lumbricoides copies/reaction) was used to determine a high cut-off of 57.9 ng/mL 2-MPC that could be used to identify subjects with moderate-to-high infection. Moderate infection was defined as > 700 cps/rxn (see “Materials and methods” section).