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. 2020 Sep 25;11:4865. doi: 10.1038/s41467-020-18690-4

Fig. 7. External supplementation of EPA or LA rescues life-span defects of fat-2(wa17).

Fig. 7

a, b WT (a) or fat-2(wa17) (b) were grown on control or drl-1 RNAi in the presence or absence of LA or EPA. In fat-2(wa17), the drl-1 RNAi failed to increase life span. However, the life span was rescued on addition of LA or EPA. Life span was performed at 25 °C and life-span summary data is provided in Supplementary Table 1. c A model showing that p38-MAPK functions downstream of different paradigms of DR to regulate gene expression and longevity, as discovered in this study. The ‘?’ denotes unanswered questions that evolve from the study. For example, How does sFA/MUFA/PUFAs or their derivatives activate p38-MAPK? What transcription factors function downstream of p38-MAPK to regulate CyTP genes? Source data are provided as a Source data file.