Table 3.
Cox proportional hazards model estimates in the genotyped FINRISK testing subset and Estonian validation cohort in relation to all-cause mortality.
| Model | FINRISK (testing subset with genotypes) | Estonian Biobank | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Components | Medications | Comorbidities | Polygenic risk scores | HRMed | HRComorb | C-index | p-value (removed variables) | HRMed | HRComorb | C-index | p-value (removed variables) |
| BL | 0.779 (0.757–0.801) | 0.775 (0.767–0.784) | |||||||||
| BL + CI | ✓ | 1.76 (1.56–1.98) | 0.794 (0.773–0.815) | 2.80e−16 (CI) | 1.15 (1.13–1.17) | 0.790 (0.782–0.798) | 2.16e−49 (CI) | ||||
| BL + M | ✓ | 1.18 (1.14–1.22) | 0.794 (0.773–0.815) | 2.25e−16 (M) | 1.19 (1.17–1.22) | 0.791 (0.783–0.799) | 3.82e−69 (M) | ||||
| BL + M + CI | ✓ | ✓ | 1.13 (1.08–1.17) | 1.50 (1.31–1.70) | 0.802 (0.781–0.822) |
2.49e−8 (M) 3.15e−8 (CI) |
1.15 (1.12–1.17) | 1.09 (1.06–1.11) | 0.796 (0.788–0.804) |
1.13e−46 (M) 8.13e−17 (CI) |
|
| BL + M + CI + PRS | ✓ | ✓ | ✓ | 1.13 (1.08–1.17) | 1.50 (1.31–1.70) | 0.803 (0.782–0.823) | 0.69 (PRS) | ||||
B baseline (age and sex covariates), M medication score, CI Charlson Comorbidity Index, PRS polygenic risk scores. Confidence intervals (95%) for estimates provided where applicable.