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. 2020 Sep 25;11(9):805. doi: 10.1038/s41419-020-03015-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The SCID mice bearing pCan1 colon cancer xenografts were treated with A1874 (20 mg/kg body weight, oral administration, daily for 21 days) or the vehicle control (“Veh”); Tumor volumes (a) and mice body weights (d) were recorded weekly. The estimated daily tumor growth was calculated by using the described formula (b). At Day-42/D42, tumors of the two groups were isolated and weighted (c). At treatment Day7 (D7), one tumor of each group was isolated, and tumors were homogenized. Expression of the listed proteins in tumor tissue lysates was tested (e, f). The GSH/GSSG ratio in tumor tissue lysates was examined (g). Expression of listed proteins was quantified and normalized to the loading control (e, f). Data were presented as mean ± standard deviation (SD). *P < 0.05 vs. “Veh” group.