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. 2020 Sep 25;10:15790. doi: 10.1038/s41598-020-72801-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Serum levels of AST and ALT in %. (A) Serum values of AST are depicted as box plots with an indication of the median value. Whiskers are determined using the Tukey method (1.5 × IQR). (B) Individual AST values in the three experimental groups are given. Type III ANOVA F(2; 85) = 7.6130; week 2: CCl₄ vs control; ***p < 0.001, p_adj < 0.0001; week 2: CCl₄ vs handling; ***p < 0.001 p_adj < 0.0001. (C) Serum values of ALT with indication of the median value (D) Individual ALT values of all experimental groups. Type III ANOVA F(2;20.54) = 3.6966; week 2: CCl₄ vs. Control; ***p < 0.001; p_adj < 0.0001; week 2: CCl₄ vs handling; ***p < 0.001 p_adj < 0.0001. The graphs were generated using the R software version (3.6.2) (R Core Team (2017). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/).