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. 2020 Sep 25;10:15790. doi: 10.1038/s41598-020-72801-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Histological analysis of liver tissue after 4 weeks of treatment (CCl₄, control) and microscopic images of liver sections (CCl₄, control, handling) in Masson Goldner staining (× 20). Collagen deposits are indicated as pale blue colored tissue (A) Histology index. Two-way ANOVA F(3, 304) = 142.6 ****p < 0.001(Sidak corrections for multiple comparisons) p_adj = < 0.0001. (B) Degree of fibrosis. (C) Planimetric analysis. ****p < 0.0001 t-test, Mann–Whitney, non-parametric. (D) Correlation of planimetry and histology index. r = 0.95; r² = 0.91; 95% confidence interval 0.8729 to 0.9834. (E) Representative image of a liver section showing moderate fibrosis in the CCl₄ group (F) a section obtained from a control animal and (G) histological appearance of liver section obtained from a handling group animal. The graphs were generated using GraphPad Prism version 7.00 for Windows (GraphPad Software, La Jolla California USA, www.graphpad.com).