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. 2020 Sep 25;11(9):802. doi: 10.1038/s41419-020-03003-w

Fig. 1. Lipotoxic effects mediated by FFAs contribute to NAFLD progression.

Fig. 1

FFAs-induced lipotoxicity promotes ER and oxidative stress, insulin resistance and impairs autophagy. As a consequence, FFAs activate apoptotic cascades thus promoting tissue damage and inflammation. Altogether, these molecular events contribute to NAFLD progression.