Table 2.

Druggable genetic targets associated with multiple sclerosis prioritized by multi-omic SMR

Chromosome	Methylation probe	Ensembl gene ID	Gene	Druggability tier	Replicated in CAGE
20	cg01943874	ENSG00000101017	CD40	Tier 1	Yes
20	cg17929951	ENSG00000101017	CD40	Tier 1	Yes
20	cg19785066	ENSG00000101017	CD40	Tier 1	Yes
20	cg21601405	ENSG00000101017	CD40	Tier 1	Yes
20	cg25239996	ENSG00000101017	CD40	Tier 1	Yes
2	cg04202892	ENSG00000153208	MERTK	Tier 1	Yes
2	cg08443563	ENSG00000153208	MERTK	Tier 1	Yes
2	cg18646521	ENSG00000153208	MERTK	Tier 1	Yes
1	cg23712594	ENSG00000143799	PARP1	Tier 1	Yes
11	cg23844623	ENSG00000025434	NR1H3	Tier 2	Yes
11	cg25783544	ENSG00000025434	NR1H3	Tier 2	Yes
11	cg26365553	ENSG00000025434	NR1H3	Tier 2	Yes
11	cg23844623	ENSG00000134575	ACP2	Tier 3A	Yes
11	cg25783544	ENSG00000134575	ACP2	Tier 3A	Yes
11	cg26365553	ENSG00000134575	ACP2	Tier 3A	Yes
1	cg08786003	ENSG00000160856	FCRL3	Tier 3A	Yes
1	cg19602479	ENSG00000160856	FCRL3	Tier 3A	Yes
1	cg25259754	ENSG00000160856	FCRL3	Tier 3A	Yes
1	cg09808235	ENSG00000142606	MMEL1	Tier 3A	Yes
1	cg12750103	ENSG00000142606	MMEL1	Tier 3A	Yes
1	cg26783079	ENSG00000142606	MMEL1	Tier 3A	Yes
11	cg01637289	ENSG00000167286	CD3D	Tier 3B	Yes
17	cg09639931	ENSG00000141736	ERBB2	Tier 1	No
11	cg08904394	ENSG00000173511	VEGFB	Tier 1	No
22	cg05329888	ENSG00000025708	TYMP	Tier 2	No
22	cg09435190	ENSG00000025708	TYMP	Tier 2	No
22	cg11654620	ENSG00000025708	TYMP	Tier 2	No
22	cg16367976	ENSG00000025708	TYMP	Tier 2	No
22	cg22927510	ENSG00000025708	TYMP	Tier 2	No
11	cg01637289	ENSG00000160593	AMICA1	Tier 3A	No
8	cg01069256	ENSG00000104432	IL7	Tier 3A	No
8	cg05575058	ENSG00000104432	IL7	Tier 3A	No
11	cg19088912	ENSG00000175294	CATSPER1	Tier 3B	No
22	cg03321319	ENSG00000100023	PPIL2	Tier 3B	No
22	cg25898577	ENSG00000100023	PPIL2	Tier 3B	No

If the association was replicated at all three stages in the CAGE dataset, this is indicated in the final column.

CAGE: Consortium for the Architecture of Gene Expression.