FIGURE 4.

Electrophysiological characteristics of NIS‐RhiPSC‐CMs. A, Coupling of action potential (top) and Ca²⁺ flux (bottom), shown via simultaneous recording by patch clamp and Ca²⁺ fluorescence imaging of three different cardiomyocyte subtypes derived from NIS‐RhiPSCs. B, Baseline electrophysiological parameters of NIS‐RhiPSC‐CMs and control RhiPSC‐CMs by whole‐cell patch clamp in each of the CM subtypes, expressed as mean ± SEM. Statistical analysis between NIS‐RhiPSC‐CMs and control RhiPSC‐CMs was performed with a t test for independent samples. *P < .05. RhiPSC‐CMs, rhesus macaque induced pluripotent stem cell‐derived cardiomyocytes