Table 1.
Outcomes of Request for Phage Therapy Received at IPATH From June 1, 2018, to April 30, 2020, Based on Infecting Bacterial Pathogen
| Number of Requests | Phage Hunt Initiated | Lytic Phage(s) Found | Phage Therapy Administered | Phage Therapy Pending | Median Time From Request to Administration (Range), d | |
|---|---|---|---|---|---|---|
| Pseudomonas aeruginosa | 92 | 26 | 18 | 5 | 1 | 156.5 (58–374) |
| Escherichia coli | 39 | 6 | 4 | 2 | 2 | 260 (165–355) |
| Klebsiella pneumoniae | 27 | 2 | 0 | 0 | 0 | - |
| Acinetobacter baumannii | 14 | 1 | 0 | 0 | 0 | - |
| Achromobacter species | 8 | 5 | 2 | 0 | 1 | - |
| Enterobacter cloacae | 6 | 2 | 2 | 0 | 1 | - |
| Enterobacter aerogenes | 1 | 1 | 1 | 1 | 0 | 252 |
| Enterobacter species | 2 | 0 | 0 | 0 | 0 | - |
| Serratia marcescens | 4 | 1 | 1 | 0 | 0 | - |
| Citrobacter species | 1 | 1 | 1 | 1 | 0 | 53 |
| Burkholderia cenocepacia | 8 | 6 | 0 | 0 | 0 | - |
| Burkholderia cepacia | 10 | 6 | 1 | 0 | 0 | - |
| Burkholderia gladioli | 1 | 1 | 0 | 0 | 0 | - |
| Bacillus vietnamensis | 1 | 1 | 0 | 0 | 0 | - |
| Pandoraea pulmonicola | 1 | 1 | 0 | 0 | 0 | - |
| Ralstonia mannitolilytica | 1 | 1 | 0 | 0 | 0 | - |
| Staphylococcus aureus | 77 | 4 | 1 | 1 | 0 | 28 |
| Staphylococcus epidermidis | 2 | 0 | 0 | 0 | 0 | - |
| Staphylococcus lugdunensis | 1 | 1 | 0 | 0 | 0 | - |
| Enterococus faecalis | 10 | 0 | 0 | 0 | 0 | - |
| Enterococcus faecium | 2 | 2 | 2 | 2 | 0 | 127 (50–204) |
| Clostridiodes difficile | 8 | 0 | 0 | 0 | 0 | - |
| Mycobacterium abscessus | 47 | 18 | 9 | 4 | 3 | 176 (87–386) |
| Mycobacterium chimera | 7 | 5 | 4 | 1 | 0 | 168 |
| Mycobacterium avium | 23 | 1 | 0 | 0 | 0 | - |
| Mycobacterium smegatis | 1 | 0 | 0 | 0 | 0 | - |
| Mycobacterium chelonae | 2 | 0 | 0 | 0 | 0 | - |
| Mycobacterium xenopi | 1 | 0 | 0 | 0 | 0 | - |
| Mycobacterium bolletii | 1 | 0 | 0 | 0 | 0 | - |
| Mycobacterium genavense | 1 | 0 | 0 | 0 | 0 | - |
| Mycobacterium species | 7 | 0 | 0 | 0 | 0 | - |
| Borrelia burgdorferi | 37 | 0 | 0 | 0 | 0 | - |
| Other organisms | 45 | 0 | 0 | 0 | 0 | - |
| Polymicrobial | 86 | 7 | 1 | 0 | 1 | - |
| Not applicable | 141 | 0 | 0 | 0 | 0 | - |
| Missing organism name | 70 | 0 | 0 | 0 | 0 | - |
| Total | 785 | 99 | 47 | 17 | 9 | Overall median, 170.5 (28–386) |
Among 17 cases who received phage therapy during this time period, 4 were treated at IPATH. This included cases of infection due to Pseudomonas aeruginosa (n = 2), Staphylococcus aureus (n = 1), and Escherichia coli (n = 1).
Abbreviation: IPATH, Center for Innovative Phage Applications and Therapeutics.