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. 2020 Sep 22;13:9377–9388. doi: 10.2147/OTT.S261700

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© 2020 Liu et al.

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Paclitaxel exerted its function through regulating circ-BIRC6 in HCC cells. (A) The expression of circ-BIRC6 determined by qRT-PCR in Huh-7 and Hep3B cells treated with different concentrations of paclitaxel (2 nM, 1020 nM). (B–F) Huh-7 and Hep3B cells were divided into 4 groups: Control, paclitaxel, paclitaxel + pcDNA, paclitaxel + circ-BIRC6. (B) Circ-BIRC6 abundance was tested by qRT-PCR in treated Huh-7 and Hep3B cells. (C and D) CCK-8 assay was conducted to evaluate cell viability in treated Huh-7 and Hep3B cells. (E) The number of colonies was measured by colony formation assay in treated Huh-7 and Hep3B cells. (F) Cell apoptosis was determined using flow cytometry analysis in treated Huh-7 and Hep3B cells. *P<0.05.