Table 5.
Blood Gas Values and Hemodynamic Metrics for Control, LCT and LCT/MCT Groups 120 Minutes and 72 Hours After Onset of Resuscitation in Experiment A
| Control | LCT | LCT/MCT | |
|---|---|---|---|
| At 120 Minutes | |||
| pH | 7.19±0.07 | 7.26±0.07 | 7.32±0.08†† |
| PO2, mmHg | 153±28 | 217±24*** | 236±29††† |
| PCO2, mmHg | 38±3 | 40±3 | 40±2 |
| HCO3−, mmol/L | 17.3±1.7 | 19.1±1.2* | 20.6±1.7†††,‡ |
| BE, mmol/L | −10.3±1.3 | −7.7±2.8* | −4.7±3.1†††,‡ |
| Lactate, mmol/L | 10.2±1.5 | 7.6±2.7* | 6.5±2.4†† |
| HR, beat/min | 292±2 | 335±16*** | 334±15††† |
| MAP, mmHg | 61±2 | 85±6*** | 87±6††† |
| RPP, mmHg*beat/min | 24520±974 | 39191±3032*** | 39108±2207††† |
| After 72 Hours | |||
| pH | 7.28±0.08 | 7.38±0.03* | 7.37±0.03† |
| PO2, mmHg | 91±12 | 116±15*** | 113±10†† |
| PCO2, mmHg | 37±2 | 38±3 | 39±3 |
| HCO3−, mmol/L | 19.9±1.7 | 23.0±2.3** | 22.9±1.5†† |
| BE, mmol/L | −5.1±2.1 | −3.3±1.4* | −2.8±1.3†† |
| Lactate, mmol/L | 5.5±2.1 | 3.2±1.6* | 3.4±1.7† |
| HR, beat/min | 307±12 | 340±13*** | 337±12††† |
| MAP, mmHg | 71±7 | 85±5*** | 83±7††† |
| RPP, mmHg*beat/min | 28617±2546 | 41918±2992*** | 41506±2501††† |
Notes: The Control, LCT and LCT/MCT groups displayed differences in pH at 120 minutes (P=0.001); Control group vs LCT group, P=0.109; Control group vs LCT/MCT group, P=0.001; LCT group vs LCT/MCT group, P=0.063. The Control, LCT and LCT/MCT groups displayed differences in PO2 at 120 minutes (P<0.001); Control group vs LCT group, P<0.001; Control group vs LCT/MCT group, P<0.001; LCT group vs LCT/MCT group, P=0.142. The Control, LCT and LCT/MCT groups displayed differences in HCO3− at 120 minutes (P<0.001); Control group vs LCT group, P=0.027; Control group vs LCT/MCT group, P<0.001; LCT group vs LCT/MCT group, P=0.020. The Control, LCT and LCT/MCT groups displayed differences in BE at 120 minutes (P<0.001); Control group vs LCT group, P=0.016; Control group vs LCT/MCT group, P<0.001; LCT group vs LCT/MCT group, P=0.018. The Control, LCT and LCT/MCT groups displayed differences in lactate at 120 minutes (P=0.003); Control group vs LCT group, P=0.043; Control group vs LCT/MCT group, P=0.002; LCT group vs LCT/MCT group, P=0.581. The Control, LCT and LCT/MCT groups displayed differences in HR at 120 minutes (P<0.001); Control group vs LCT group, P<0.001; Control group vs LCT/MCT group, P<0.001; LCT group vs LCT/MCT group, P=0.999. The Control, LCT and LCT/MCT groups displayed differences in MAP at 120 minutes (P<0.001); Control group vs LCT group, P<0.001; Control group vs LCT/MCT group, P<0.001; LCT group vs LCT/MCT group, P=0.924. The Control, LCT and LCT/MCT groups displayed differences in RPP at 120 minutes (P<0.001); Control group vs LCT group, P<0.001; Control group vs LCT/MCT group, P<0.001; LCT group vs LCT/MCT group, P=1.000. The Control, LCT and LCT/MCT groups displayed differences in pH after 72 hours (P<0.001); Control group vs LCT group, P=0.017; Control group vs LCT/MCT group, P=0.032; LCT group vs LCT/MCT group, P=0.609. The Control, LCT and LCT/MCT groups displayed differences in PO2 after 72 hours (P<0.001); Control group vs LCT group, P<0.001; Control group vs LCT/MCT group, P=0.001; LCT group vs LCT/MCT group, P=1.000. The Control, LCT and LCT/MCT groups displayed differences in HCO3− after 72 hours (P=0.001); Control group vs LCT group, P=0.002; Control group vs LCT/MCT group, P<0.003; LCT group vs LCT/MCT group, P=1.000. The Control, LCT and LCT/MCT groups displayed differences in BE after 72 hours (P=0.005); Control group vs LCT group, P=0.029; Control group vs LCT/MCT group, P=0.005; LCT group vs LCT/MCT group, P=1.000. The Control, LCT and LCT/MCT groups displayed differences in lactate after 72 hours (P=0.009); Control group vs LCT group, P=0.011; Control group vs LCT/MCT group, P=0.021; LCT group vs LCT/MCT group, P=1.000. The Control, LCT and LCT/MCT groups displayed differences in HR after 72 hours (P<0.001); Control group vs LCT group, P<0.001; Control group vs LCT/MCT group, P<0.001; LCT group vs LCT/MCT group, P=1.000. The Control, LCT and LCT/MCT groups displayed differences in MAP after 72 hours (P<0.001); Control group vs LCT group, P<0.001; Control group vs LCT/MCT group, P<0.001; LCT group vs LCT/MCT group, P=1.000. The Control, LCT and LCT/MCT groups displayed differences in RPP after 72 hours (P<0.001); Control group vs LCT group, P<0.001; Control group vs LCT/MCT group, P<0.001; LCT group vs LCT/MCT group, P=1.000. No significant differences were demonstrated among the three groups in PCO2 at 120 minutes or 72 hours after onset of resuscitation. All values are mean ± SD. *Control group vs LCT group, †Control group vs LCT/MCT group, ‡LCT group vs LCT/MCT group. *P<0.05, †P<0.05, ‡P<0.05, **P<0.01, ††P<0.01, ***P<0.001, †††P<0.001.
Abbreviations: PO2, partial pressure of oxygen; PCO2, partial pressure of carbon dioxide; HCO3−, bicarbonate radical; BE, base excess; HR, heart rate; MAP, mean arterial pressure; RPP, heart rate pressure product.