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. 2020 Sep 22;15:6975–6991. doi: 10.2147/IJN.S269069

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© 2020 Dong et al.

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Host cells infiltration induced by allogeneic and xenogeneic sEV-AT in vivo. Host cells infiltration in tubes was measured at 3D, 5D and 7D. (A) Schematic view of the experimental operation process. Matrigel only, or mixed with r-sEV-AT and p-sEV-AT was transferred into the custom-designed silicone tube and subcutaneously implanted it into the back of SD rats. After 3D, 5D and 7D implantation, samples with the tubes were photographed. (B) Macro images of the implants after removing the tubes. (C) Host cells infiltration was confirmed by H&E staining. The solid lines represented the lower edge of the sheet-like panniculus carnosus skeletal muscle in the skin, the dotted lines represented the position where the cell density is significantly reduced and the black arrows represented the thickness of cell infiltration. Scale bar = 200 μm. (D) The average thickness of cells infiltration in different groups (n=3). The significance was tested with one-way ANOVA with Tukey posthoc test (**p<0.01, ***p <0.001).

Abbreviations: p-sEV-AT, small extracellular vesicles derived from porcine adipose tissue; r-sEV-AT, small extracellular vesicles derived from rat adipose tissue; sEV-AT, small extracellular vesicles.