Figure 6.

Skin wound healing in microstructure was improved by allogeneic and xenogeneic sEV-AT. (A) The microstructure of skin wounds at 10D was investigated by H&E staining. The black inverted triangles pointed out the original wound edges; the red inverted triangles pointed out the edge of re-epithelization; the black arrows pointed out the regenerated hair follicles; the orange star pointed out the disordered wound area. Magnified panels (B) the red inverted triangles pointed out the edge of re-epithelization; the dotted red lines pointed out the area of regenerated epithelium; the black two-way arrows pointed out the thickness of regularly arranged granulation tissue. Scale bar = 200 μm. (C) Quantification of the length of regenerated epidermal tongue at 10D. (D) Quantification of the thickness of granulation tissue at 10D (n=3).

Abbreviations: H&E, hematoxylin and eosin; p-sEV-AT, small extracellular vesicles derived from porcine adipose tissue; r-sEV-AT, small extracellular vesicles derived from rat adipose tissue; sEV-AT, small extracellular vesicles derived from adipose tissue.