. Author manuscript; available in PMC: 2020 Sep 26.

Published in final edited form as: Neurobiol Dis. 2020 Apr 30;141:104877. doi: 10.1016/j.nbd.2020.104877

Table 5.

Overlap between cell-type-specific DEGs (pval <0.05) with genes mapped to GW AS hits (pval <10E-5). (details in Supplementary Table 7).

Cell type DEGs	Enrichment P value	FDR	DEGs (p < .05) overlapping with top GWAS hits (GWAS pval < 10E-5) (up-regulation in SOD1 mutant shown in bold)
INT1 DEG (down)	1.04E-04	0.0012	WHAMM, AXIN1, TUSC1, CHRNB1, SEC13
Endothelial DEG (down)	1.20E-04	0.0013	MAP3K3, BAZ2A, ZBTB4
Neurons2 DEG (up)	5.20E-4	0.0044
Sensory DEG (up)	0.0023	0.0148
Microglia DEG (up)	0.0380	0.1760	*SYNGR1*
MO DEG (down)	0.0509	0.2161	FNBP1, PTGES3, ACTR2