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Mechanism of action of pharmacological agents targeting the NO/sGC and neprilysin/pGC pathways to increase cGMP generation. cGMP, 3′,5′-cyclic guanosine monophosphate; GTN, glyceryl trinitrate; GTP, guanosine triphosphate; ISDN, isosorbide dinitrate; NO, nitric oxide; NOS, nitric oxide synthase; PDE, phosphodiesterase; pGC, particulate guanylate cyclase; sGC, soluble guanylate cyclase. Adapted from Friebe et al.13
