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. 2019 Nov 9;116(12):2021–2030. doi: 10.1093/cvr/cvz304

Figure 4.

Figure 4

TSP-1 deletion in the bone marrow (BM) compartment decreases Rho-kinase signalling and vasoconstriction induced by hypoxia. Active (GTP-bound) RhoA concentration in (A) normoxia and 21-days of chronic hypoxia exposed wild-type (WT) mice, and (B) in WT recipients of WT or Thbs1−/− BM. (C) RVSP before and after Fasudil treatment in WT recipients of WT or Thbs1−/− BM and (D) the relative drop in RVSP resulting from Fasudil treatment (pre-minus post-pressures) (mean ± SD plotted; N, number of animals per group; A, B, and D unpaired, whereas C paired t-test: *P < 0.05, ***P < 0.005, ****P < 0.001).