Table 2.
Studies assessing sarcopenia in patients undergoing liver resection
| Author (year) | Region | N. patients | Outcome | Methods for sarcopenia assessment | N. of sarcopenic patients | Cut off |
|---|---|---|---|---|---|---|
| Fan (1994) [17] | Asia | 124 (64 nutritional support group vs 60 control) | Complications after surgery |
Midarm circumference Triceps skin-fold thickness HGS |
– | – |
| Harimoto (2013) [18] | Asia | 186 |
OS Recurrence |
L3-SMI at CT | 75 |
M: < 43,75 cm2/m2 W: < 41,10 cm2/m2 |
| Dello (2013) [19] | Europe | 40 | TFLV | L3-SMI at CT | 27 |
M: < 55.4 cm2/m2 W: < 38.9 cm2/m2 |
| Voron (2015) [20] | Europe | 109 |
Mortality Recurrence |
L3-SMI at CT | 59 |
M: < 52.4 cm2/m2 W: < 38.9 cm2/m2 |
| Otsuji (2015) [21] | Asia | 256 |
Hospital stay Complications after surgery PHLF |
TPA/ height | 85 |
M: < 536 cm2/m2 W: < 378 cm2/m2 |
| Takagi (2016) [22] | Asia | 254 | 5-year OS | L3-SMI at CT | 118 |
M: < 46.4 cm2/m2 W: < 37.6 cm2/m2 |
| Yabusaki (2016) [23] | Asia | 195 | Recurrence | L3-SMI at CT | 89 |
M: < 43,75 cm2/m2 W: < 41,10 cm2/m2 |
| Hamaguchi (2019) [24] | Asia | 606 |
Mortality Recurrence |
VSR L3-SMI L3-IMAC |
– |
VSR M: < 1.325 W: < 0.710 SMI M: < 40.31 cm2/m2 W: < 30.88 cm2/m2 IMAC M: < -0.358 HU W: < -0.229 HU |
| Kobayashi (2019) [25] | Asia | 465 |
Mortality Recurrence |
L3-SMI visceral adipose tissue area |
Sarcopenic non- obesity = 31 Sarcopenic obesity = 31 |
M: < 40.31 cm2/m2 W: < 30.88 cm2/m2 > 100 cm2 |
N. Number, HGS Handgrip strength, OS Overall Survival, L3 third lumbar vertebra, SMI cross-sectional areas of skeletal muscle (cm2)/patient’s height (m2), CT computed tomography, M male, W women, TFLV total functional liver volume, TPA total psoas muscle area, PHLF post-hepatectomy liver failure, VSR visceral adipose tissue area (cm2)/sub- cutaneous adipose tissue area (cm2), CT attenuation value of the multifidus muscles (HU)/CT attenuation value of the subcutaneous fat (HU) (IMAC)