Table 3.
Studies assessing sarcopenia in patients undergoing liver transplantation
| Author (year) | Region | N. patients (N. HCC patients) | Outcome | Methods for sarcopenia assessment | N. of sarcopenic patients | Cut off |
|---|---|---|---|---|---|---|
| Krell (2013) [28] | America | 207 (52) | Infections | TPA | – | – |
| Di Martini (2013) [29] | America | 338 (NA) |
Hospital stay Intensive unit stay |
SMI | 68 |
M: < 53.4 cm2/m2 W: < 38.5 cm2/m2 |
| Kaido (2013) [30] | Asia | 124 (39) | Survival after LT | Skeletal muscle mass by BIA | 47 | < 90% of the standard |
| Durand (2014) [31] | Europe | 562 (258) | Mortality | TPMT/height | – | – |
| Lee (2014) [32] | America | 325 (127) |
1 y-Mortality 5 y-Mortality |
L4-TPA T12-Dorsal muscle area |
– | – |
| Montano-Loza (2014) [33] | America | 248 (97) |
Hospital stay Infections |
L3-SMI SMA |
112 |
M: < 53 cm2/m2 if BMI > 25 < 43 cm2/m2 if BMI < 25 W: < 41 cm2/m2 SMA < 41 HU if BMI < 24.9 < 33 if BMI > 25 |
| Montano-Loza (2015) [34] | America | 669 (291) | Mortality | L3-SMI | 298 |
M: < 53 cm2/m2if BMI > 25 < 43 cm2/m2if BMI < 25 W: < 41 cm2/m2 |
| Underwood (2015) [35] | America | 348 (95) | Failure to rescue | TPA | – | – |
| Valero (2015) [36] | America | 96 (67) |
Surgical complications Mortality |
L3-TPA TPV |
44 by TPA 47 by TPV |
M: < 680.4 mm2/m2 W: < 524.7 mm2/m2 |
| Jeon (2015) [37] | Asia | 145 (96) | Mortality | SMI |
52 pre LT 66 post LT |
M: < 7.7 cm2/m2if 20–50 years, < 6.6 cm2/m2if > 50 years W: 4.6 cm2/m2 if 20–50 years, < 4.4 cm2/m2 > 50 years |
| Carey (2016) [38] | America | 396 (155) | Mortality | L3-SMI | 178 |
M < 50 cm2/m2 W: < 39 cm2/m2 |
| Itoh (2016) [39] | Asia | 153 (153) | Surgical Outcome | SVR by TC | 38 | – |
| Van Vugt (2017) [40] | Europe | 585 (193) | Mortality | L3-SMI | 254 |
M: < 53 cm2/m2 if BMI > 25 < 43 cm2/m2 if BMI < 25 W: < 41 cm2/m2 |
| Wada (2017) [41] | Asia | 32 (2) | Respiratory complications |
TPA TPV |
16 |
TPA M: < 791.6 mm2/m2 W: < 488.8 mm2/m2 TPV M: < 149 cm3/m2 W: < 83.3 cm3/m2 |
| Golse (2017) [42] | Europe | 256 (102) |
Intensive unite stay Complications mortality |
PMA SMI |
57 |
PMA M: < 1561 mm2 F < 1464 mm2 |
| Chae (2018) [43] | Asia | 408 (191) |
Mortality Complications |
Δ PMI | 102 | <—11.7% |
| Kim (2018) [44] | Asia | 92 (92) | Recurrence | height-normalized Psoas muscle thickness | 72 | < 15.5 mm/m |
N Number, TPA total psoas muscle area, SMI cross-sectional areas of skeletal muscle (cm2)/patient’s height (m2) , TPMT/height transversal psoas muscle thickness (mm) /height (m), L4 fourth lumbar vertebra, TPA total psoas muscle area, T12 twelfth thoracic vertebrae, L3 third lumbar vertebra, HU transversal psoas muscle attenuation TPV total psoas muscle volume, PMA psoas muscle area, PMI psoas muscle index, SVR muscle mass-to-visceral fat area ratio