Table 2.
Treatment and outcome of patients with juvenile and adult tGrCT
| Author | Year | No. of cases | Primary treatment (no. of patients) | Location of metastatic spread (no. of patients) | Treatment of metastatic disease (no. of patients) | Histology | Mean follow-up time in months | Outcome during follow-up (no. of patients) |
|---|---|---|---|---|---|---|---|---|
| Summary statistics | ||||||||
| All tGrCT | 239 | 140 orchiectomy, 62 gonadectomy, 20 TSS, 7 laparotomy, 2 biopsy only | 5 RPLN, 1 ILN, 1 lung, 1 liver, 1 bone |
3 RPLND, 4 Chemo, 1 ILND 1 RT, 1 metastasectomy |
48 | 121 NED, 2 local recurrence, 7 died, 18 LTFU | ||
| All juvenile tGrCT | 166 | 72 orchiectomy, 62 gonadectomy, 15 TSS, 7 laparotomy, 2 biopsy only | 0 | – | jGCT | 54 | 80 NED, 1 local recurrence, 3 died | |
| All adult tGrCT | 73 | 68 orchiectomy, 5 TSS | 5 RPLN, 1 ILN, 1 lung, 1 liver, 1 bone |
3 RPLND, 4 Chemo, 1 ILND 1 RT, 1 metastasectomy |
aGCT | 34 | 41 NED, 1 local recurrence, 4 died | |
| Single reports | ||||||||
| Trenti, E., et al. | 2018 | 1 | TSS | aGCT | 12 | NED | ||
| Tartar, T., et al. | 2017 | 1 | Orchiectomy | jGCT | ||||
| Elbachiri, M., et al. | 2017 | 1 | Orchiectomy | RPLN | Chemo (BEP) | aGCT | 6 | Contralateral recurrence (6) |
| Dundas, M., et al. | 2017 | 1 | Orchiectomy | jGCT | 7 | NED | ||
| Mohapatra, A., et al. | 2016 | 1 | Orchiectomy | RPLN | RPLND | aGCT | 32 | NED |
| Liu, S. and P. Koscheski | 2016 | 1 | TSS | jGCT | ||||
| Karachaliou, F., et al. | 2016 | 1 | jGCT | 18 | NED | |||
| Bani, M. A., et al. | 2016 | 1 | Orchiectomy | aGCT | 4 | NED | ||
| Al-Alao, O., et al. | 2016 | 1 | Orchiectomy | aGCT | 12 | NED | ||
| Vallonthaiel, A. G., et al. | 2015 | 1 | Orchiectomy | aGCT | LTFU | |||
| Kao, Chia-Sui | 2015 | 70 | 62 gonadectomy, 6 TSS, 2 biopsy only | jGCT | 61 | 24 NED | ||
| González, B. I., et al. | 2015 | 1 | Orchiectomy | jGCT | ||||
| Giulianelli, R., et al. | 2015 | 1 | Orchiectomy | aGCT | 12 | NED | ||
| Bani, M. A., et al. | 2015 | 1 | Orchiectomy | aGCT | LTFU | |||
| Tsitouridis, I., et al. | 2014 | 1 | Orchiectomy | aGCT | 12 | NED | ||
| Tanner, S. B., et al. | 2014 | 1 | Orchiectomy | aGCT | NED | |||
| Schubert, T. E. O., et al. | 2014 | 1 | Orchiectomy | aGCT | LTFU | |||
| Illescas, T., et al. | 2014 | 1 | Orchiectomy | jGCT | LTFU | |||
| Cosentino, M., et al. | 2014 | 1 | Orchiectomy | jGCT | LTFU | |||
| Cornejo, K. M. and R. H. Young | 2014 | 32 | 30 orchiectomy, 2 TSS | aGCT | 37 | 17 NED, 1 orchiectomy | ||
| Claros, O. R., et al. | 2014 | 1 | Orchiectomy | jGCT | 48 | NED | ||
| Aranha, A., et al. | 2014 | 1 | Orchiectomy | jGCT | 24 | NED | ||
| Norman, R. W., et al. | 2013 | 1 | Orchiectomy | aGCT | 18 | NED | ||
| Miliaras, D., et al. | 2013 | 1 | Orchiectomy | aGCT | 24 | NED | ||
| Partalis, N., et al. | 2012 | 1 | jGCT | 12 | NED | |||
| Muhlschlegel, J. M., et al. | 2012 | 1 | TSS | jGCT | 24 | NED | ||
| Couture, J. and S. Bolduc | 2012 | 1 | Orchiectomy | jGCT | ||||
| Bulotta, A. L., et al. | 2012 | 1 | Orchiectomy | jGCT | 1 | NED | ||
| Yu, D. C., et al. | 2011 | 1 | Orchiectomy | jGCT | 17 | NED | ||
| Tiscione, D., et al. | 2011 | 1 | TSS | aGCT | LTFU | |||
| Song, Z., et al. | 2011 | 1 | Orchiectomy | aGCT | LTFU | |||
| Zugor, V., et al. | 2010 | 2 | 2 orchiectomy | jGCT | 17 | 2 NED | ||
| Seixas-Mikelus, S. A., et al. | 2010 | 1 | Orchiectomy | jGCT | 12 | NED | ||
| Oscar Tapia, E., et al. | 2010 | 1 | Orchiectomy | jGCT | 8 | NED | ||
| Gun, F., et al. | 2010 | 3 | 2 orchiectomy, 1 TSS | jGCT | ||||
| Cecchetto, G., et al. | 2010 | 5 | 3 TSS | jGCT | ||||
| Peterson, C. and S. Skoog | 2008 | 1 | Orchiectomy | jGCT | LTFU | |||
| Mitra, A., et al. | 2008 | 1 | Orchiectomy | aGCT | LTFU | |||
| Lin, K.-H., et al. | 2008 | 1 | Orchiectomy | jGCT | 96 | NED | ||
| Kucukodaci, Z., et al. | 2008 | 1 | Orchiectomy | aGCT | 10 | NED | ||
| Kim, D. J., et al. | 2008 | 1 | Orchiectomy | aGCT | 12 | NED | ||
| Hammerich, K. H., et al. | 2008 | 1 | Orchiectomy | Lung | Chemo (BEP) | aGCT | 13 | NED |
| Gupta, A., et al. | 2008 | 1 | Orchiectomy | aGCT | 12 | NED | ||
| Dudani, R., et al. | 2008 | 1 | Orchiectomy | jGCT | 6 | NED | ||
| Yikilmaz, A. and E. Y. Lee | 2007 | 1 | jGCT | |||||
| Trobs, R. B., et al. | 2007 | 1 | Orchiectomy | jGCT | 47 | NED | ||
| Lopez, J. I. | 2007 | 1 | Orchiectomy | aGCT | 12 | NED | ||
| Gravas, S., et al. | 2007 | 1 | TSS | jGCT | 18 | NED, ipsilateral recurrence (3 mo) | ||
| Ditonno, P., et al. | 2007 | 1 | Orchiectomy | aGCT | LTFU | |||
| Barroca, H., et al. | 2007 | 1 | Orchiectomy | jGCT | ||||
| Alexiev, B. A., et al. | 2007 | 1 | Orchiectomy | jGCT | ||||
| Zugor, V., et al. | 2006 | 1 | Orchiectomy | jGCT | 12 | NED | ||
| Hisano, M., et al. | 2006 | 1 | Orchiectomy | aGCT | 48 | NED | ||
| Arzola, J., et al. | 2006 | 1 | Orchiectomy | aGCT | 9 | NED | ||
| Suppiah, A., et al. | 2005 | 1 | Orchiectomy | Bone | Metastasectomy | aGCT | 4 | NED |
| Shukla, A. R., et al. | 2004 | 3 | 2 orchiectomy, 1 TSS | jGCT | 78 | 3 NED | ||
| Guzzo, T., et al. | 2004 | 1 | Orchiectomy | aGCT | LTFU | |||
| Moore, W., et al. | 2003 | 1 | Orchiectomy | jGCT | ||||
| Fidda, N. and D. A. Weeks | 2003 | 1 | Orchiectomy | jGCT | 18 | NED | ||
| Fagin, R., et al. | 2003 | 1 | Orchiectomy | jGCT | 6 | NED | ||
| Bryan, D. E., et al. | 2003 | 3 | 3 orchiectomy | jGCT | 8 | 2 NED | ||
| Wang, B. Y., et al. | 2002 | 1 | TSS | aGCT | LTFU | |||
| Nieto, N., et al. | 2002 | 1 | Orchiectomy | jGCT | 30 | NED | ||
| Antunes, L., et al. | 2002 | 1 | Orchiectomy | jGCT | ||||
| Ji, E. K. and K. S. Cho | 2001 | 1 | Orchiectomy | aGCT | LTFU | |||
| Al-Bozom, I. A., et al. | 2000 | 1 | Orchiectomy | aGCT | 7 | NED | ||
| Harms, D. and L. R. Kock | 1997 | 11 | 8 orchiectomy, 1 TSS | jGCT | 8 NED, 3 LTFU | |||
| Chan, Y. F., et al. | 1997 | 2 | 2 orchiectomy | jGCT | 9 | 2 NED | ||
| Perez-Atayde, A. R., et al. | 1996 | 6 | 6 orchiectomy | jGCT | 6 NED, 1 died | |||
| Goswitz, J. J., et al. | 1996 | 4 | 4 orchiectomy | jGCT | 96 | 3 NED, 1 LTFU, 1 died | ||
| Berensztein, E., et al. | 1995 | 1 | Orchiectomy | jGCT | ||||
| Tanaka, Y., et al. | 1994 | 1 | Laparotomy | jGCT | 72 | NED | ||
| Jimenez-Quintero, L. P., et al. | 1993 | 7 | 7 orchiectomy | P1: RPLN, liver P2: RPLN, ILN |
P1: 1 RPLND, Chemo (CD) P2: RPLND, Chemo (E), INLD, RT |
aGCT | 23 | 3 NED, 2 died (32 mo, 134 mo) |
| Nistal, M., et al. | 1992 | 1 | Orchiectomy | aGCT | 24 | NED | ||
| May, D., et al. | 1992 | 1 | Laparotomy | jGCT | 6 | NED | ||
| Matoska, J., et al. | 1992 | 1 | Orchiectomy | RPLN | RPLND, RT | aGCT | 168 | NED |
| Yokoyama, J., et al. | 1990 | 1 | Orchiectomy | jGCT | 24 | NED | ||
| Due, W., et al. | 1990 | 1 | Orchiectomy | aGCT | 2.25 | Died | ||
| Chan, J. K., et al. | 1990 | 1 | Laparotomy | jGCT | 30 | NED | ||
| Gaylis, F. D., et al. | 1989 | 1 | Orchiectomy | aGCT | LTFU | |||
| Nistal, M., et al. | 1988 | 1 | Orchiectomy | jGCT | 24 | NED | ||
| Uehling, D. T., et al. | 1987 | 1 | Orchiectomy | jGCT | 36 | NED | ||
| Raju, U., et al. | 1986 | 1 | Laparotomy | jGCT | 60 | NED | ||
| Young, R. H., et al. | 1985 | 3 | 3 laparotomy | jGCT | 6 | NED | ||
| Talerman, A. | 1985 | 1 | Orchiectomy | aGCT | 36 | NED | ||
| Pinto, M. M. | 1985 | 1 | Orchiectomy | jGCT | ||||
| Lawrence, W. D., et al. | 1985 | 14 | 14 orchiectomy | jGCT | 4 NED | |||
| Crump, W. D. | 1983 | 1 | jGCT | 0 | Died after birth | |||
aGCP adult granulosa cell tumor, jGCP juvenile granulosa cell tumor, MFS metastatic-free survival, RPLND retroperitoneal lymph node dissection, ILN inguinal lymph nodes, ILND inguinal lymph node dissection, RT radiotherapy, DOD died of disease, NED no evidence of disease, SD stable disease, Chemo: BEP bleomycin, etoposide, cisplatin, DC doxorubicin–cisplatin, E etoposide